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The antibody against AGRP was raised in rabbit using the Recombinant Human Agouti-related protein (83-132AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
The antibody against AGRP was raised in rabbit using the Recombinant Human Agouti-related protein (83-132AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
$299.00
Immunohistochemistry of paraffin-embedded human testis tissue using AGRP Antibody at dilution of 1:100
Immunohistochemistry of paraffin-embedded human adrenal gland tissue using AGRP Antibody at dilution of 1:1002
| Cat.No | ADC-44824A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | AGRP |
| Target Synonyms | Agouti related neuropeptide antibody; Agouti Related Protein Homolog antibody; Agouti-related protein antibody; Agrp antibody; AGRP_HUMAN antibody; AGRT antibody; ART antibody; ASIP2 antibody | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IHC |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Agouti-related protein (83-132AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | O00253 |
Uniprot Id
O00253
Target Species
Human
Target Name
AGRP
Target Full Name
Agouti-related protein
Target Function
Plays a role in weight homeostasis. Involved in the control of feeding behavior through the central melanocortin system. Acts as alpha melanocyte-stimulating hormone antagonist by inhibiting cAMP production mediated by stimulation of melanocortin receptors within the hypothalamus and adrenal gland. Has very low activity with MC5R. Is an inverse agonist for MC3R and MC4R being able to suppress their constitutive activity. It promotes MC3R and MC4R endocytosis in an arrestin-dependent manner.
Target Involvement
Obesity (OBESITY)
Target Subcellular Location
Secreted. Golgi apparatus lumen.
Target Tissue Specificity
Expressed primarily in the adrenal gland, subthalamic nucleus, and hypothalamus, with a lower level of expression occurring in testis, lung, and kidney.
Target Research Area
Cardiovascular
Target Synonyms
Agouti related neuropeptide; Agouti Related Protein Homolog; Agouti-related protein; Agrp; AGRP_HUMAN; AGRT; ART; ASIP2
Target Background
This gene encodes an antagonist of the melanocortin-3 and melanocortin-4 receptor. It appears to regulate hypothalamic control of feeding behavior via melanocortin receptor and/or intracellular calcium regulation, and thus plays a role in weight homeostasis. Mutations in this gene have been associated with late on-set obesity.
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