Rabbit anti-Human AGTPBP1 Polyclonal Antibody

Uniprot Id

Q9UPW5

Target Species

Human

Target Name

AGTPBP1

Target Full Name

Cytosolic carboxypeptidase 1

Target Function

Metallocarboxypeptidase that mediates protein deglutamylation of tubulin and non-tubulin target proteins. Catalyzes the removal of polyglutamate side chains present on the gamma-carboxyl group of glutamate residues within the C-terminal tail of alpha- and beta-tubulin. Specifically cleaves tubulin long-side-chains, while it is not able to remove the branching point glutamate. Also catalyzes the removal of polyglutamate residues from the carboxy-terminus of alpha-tubulin as well as non-tubulin proteins such as MYLK. Involved in KLF4 deglutamylation which promotes KLF4 proteasome-mediated degradation, thereby negatively regulating cell pluripotency maintenance and embryogenesis.

Target Subcellular Location

Cytoplasm. Cytoplasm, cytosol. Nucleus. Mitochondrion.

Target Protein Families

Peptidase M14 family

Target Synonyms

CCP1; 1700020N17Rik; 2310001G17Rik; 2900054O13Rik; 4930445M19Rik; 5730402G09Rik; AGTPBP 1; AGTPBP1; ATP/GTP binding protein 1; ATP/GTP-binding protein 1; BB114605; Carboxypeptidase tubulin; CBPC1_HUMAN; Cytosolic carboxypeptidase 1; DKFZp686M20191; KIAA1035; MGC90651; mKIAA1035; Nervous system nuclear protein induced by axotomy; Nervous system nuclear protein induced by axotomy protein 1 homolog; nmf243; NNA1; OTTHUMP00000021581; OTTHUMP00000063553; pcd; Purkinje cell degeneration; RP11-30C23.1; Soluble carboxypeptidase; Tubulinyl Tyr carboxypeptidase; Tyrosine carboxypeptidase

Target Background

NNA1 is a zinc carboxypeptidase that contains nuclear localization signals and an ATP/GTP-binding motif that was initially cloned from regenerating spinal cord neurons of the mouse.