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The antibody against ALDH6A1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 326-535 of human ALDH6A1 (NP_005580.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
The antibody against ALDH6A1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 326-535 of human ALDH6A1 (NP_005580.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
| Cat.No | ADA-00480A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | ALDH6A1 |
| Target Synonyms | MMSDH; MMSADHA; ALDH6A1 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Mouse kidney, 22Rv1, A-431, HepG2, MCF7, Mouse liver, Rat spinal cord, SH-SY5Y | Application | ELISA, WB, IF/ICC |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 326-535 of human ALDH6A1 (NP_005580.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q02252 | Immunogen Sequence |
Uniprot Id
Q02252
Target Species
Human
Target Name
ALDH6A1
Target Full Name
Methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial
Target Function
Plays a role in valine and pyrimidine metabolism. Binds fatty acyl-CoA.
Target Involvement
Methylmalonate semialdehyde dehydrogenase deficiency (MMSDHD)
Target Subcellular Location
Mitochondrion.
Target Protein Families
Aldehyde dehydrogenase family
Target Synonyms
MMSDH; MMSADHA; ALDH6A1
Target Background
This gene encodes a member of the aldehyde dehydrogenase protein family. The encoded protein is a mitochondrial methylmalonate semialdehyde dehydrogenase that plays a role in the valine and pyrimidine catabolic pathways. This protein catalyzes the irreversible oxidative decarboxylation of malonate and methylmalonate semialdehydes to acetyl- and propionyl-CoA. Methylmalonate semialdehyde dehydrogenase deficiency is characterized by elevated beta-alanine, 3-hydroxypropionic acid, and both isomers of 3-amino and 3-hydroxyisobutyric acids in urine organic acids. Alternate splicing results in multiple transcript variants.
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