Rabbit anti-Human ALDOA Polyclonal Antibody, HRP conjugated

Uniprot Id

P04075

Target Species

Human

Target Name

ALDOA

Target Full Name

Fructose-bisphosphate aldolase A

Target Function

Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein.

Target Involvement

Glycogen storage disease 12 (GSD12)

Target Subcellular Location

Cytoplasm, myofibril, sarcomere, I band. Cytoplasm, myofibril, sarcomere, M line.

Target Protein Families

Class I fructose-bisphosphate aldolase family

Target Research Area

Metabolism

Target Synonyms

ALDA; Aldo1; ALDOA; ALDOA_HUMAN; Aldolase 1; Aldolase A; Aldolase A fructose bisphosphatase; Aldolase A fructose bisphosphate; Aldolase; fructose-bisphosphate A; Epididymis secretory sperm binding protein Li 87p; FRUCTOALDOLASE A; Fructose 1 6 bisphosphate triosephosphate lyase; Fructose bisphosphate aldolase A; Fructose bisphosphate aldolase; FRUCTOSE-1,6-BISPHOSPHATE ALDOLASE A; Fructose-bisphosphate aldolase A; Fructose-bisphosphate aldolase A Muscle-type; GSD12; HEL S 87p; Lung cancer antigen NY LU 1; Lung cancer antigen NY-LU-1; MGC10942; MGC17716; MGC17767; Muscle type aldolase; Muscle-type aldolase; RNALDOG5

Target Background

This gene encodes a member of the class I fructose-bisphosphate aldolase protein family. The encoded protein is a glycolytic enzyme that catalyzes the reversible conversion of fructose-1, 6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Three aldolase isozymes (A, B, and C), encoded by three different genes, are differentially expressed during development. Mutations in this gene have been associated with Glycogen Storage Disease XII, an autosomal recessive disorder associated with hemolytic anemia. Disruption of this gene also plays a role in the progression of multiple types of cancers. Related pseudogenes have been identified on chromosomes 3 and 10.