Rabbit anti-Human AMHR2 Polyclonal Antibody

Uniprot Id

Q16671

Target Species

Human

Target Name

AMHR2

Target Full Name

Anti-Muellerian hormone type-2 receptor

Target Function

On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone.

Target Involvement

Persistent Muellerian duct syndrome 2 (PMDS2)

Target Subcellular Location

Membrane; Single-pass type I membrane protein.

Target Protein Families

Protein kinase superfamily, TKL Ser/Thr protein kinase family, TGFB receptor subfamily

Target Synonyms

AMH type II receptor; AMHR; AMHR2; AMHR2_HUMAN; Anti Mullerian hormone receptor; type II; Anti-Muellerian hormone type II receptor; Anti-Muellerian hormone type-2 receptor; MGC141312; MIS type II receptor; MISR2; MISRII; MRII; Muellerian hormone type 2 receptor; Muellerian hormone type II receptor; Muellerian inhibiting substance type II receptor; Mullerian hormone receptor type II; Mullerian inhibiting substance type II receptor

Target Background

This gene encodes the receptor for the anti-Mullerian hormone (AMH) which, in addition to testosterone, results in male sex differentiation. AMH and testosterone are produced in the testes by different cells and have different effects. Testosterone promotes the development of male genitalia while the binding of AMH to the encoded receptor prevents the development of the mullerian ducts into uterus and Fallopian tubes. Mutations in this gene are associated with persistent Mullerian duct syndrome type II. Alternatively spliced transcript variants encoding different isoforms have been identified.