Rabbit anti-Human ANKHD1 Polyclonal Antibody

Uniprot Id

Q8IWZ3

Target Species

Human

Target Name

ANKHD1

Target Full Name

Ankyrin repeat and KH domain-containing protein 1

Target Function

May play a role as a scaffolding protein that may be associated with the abnormal phenotype of leukemia cells. Isoform 2 may possess an antiapoptotic effect and protect cells during normal cell survival through its regulation of caspases.

Target Subcellular Location

Cytoplasm.

Target Protein Families

Mask family

Target Tissue Specificity

Ubiquitous with high expression in cervix, spleen and brain. Expressed in hematopoietic cells with increased expression in leukemia cells. Isoform 2 is highly expressed in spleen with almost no expression in muscle and brain.

Target Synonyms

MASK; MASK1; VBARP; PP2500; ANKHD1

Target Background

This gene encodes a protein with multiple ankyrin repeat domains and a single KH-domain. The protein is thought to function as a scaffolding protein, and it may be involved in the regulation of caspases and thereby play an antiapoptotic role in cell survival. Alternative splicing results in multiple transcript variants, one of which generates a fusion transcript (MASK-BP3) with the downstream eIF4E-binding protein 3 (EIF4EBP3) gene, resulting in a protein comprised of the ANKHD1 sequence for the majority of the protein and a different C-terminus due to an alternate reading frame for the EIF4EBP3 segments.