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The antibody against ANO6 was raised in rabbit using the Recombinant Human Anoctamin-6 protein (12-100AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IF.
The antibody against ANO6 was raised in rabbit using the Recombinant Human Anoctamin-6 protein (12-100AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IF.
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| Cat.No | ADC-04880A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | ANO6 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IF | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Anoctamin-6 protein (12-100AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q4KMQ2 |
Uniprot Id
Q4KMQ2
Target Species
Human
Target Name
ANO6
Target Full Name
Anoctamin-6
Target Function
Small-conductance calcium-activated nonselective cation (SCAN) channel which acts as a regulator of phospholipid scrambling in platelets and osteoblasts. Phospholipid scrambling results in surface exposure of phosphatidylserine which in platelets is essential to trigger the clotting system whereas in osteoblasts is essential for the deposition of hydroxyapatite during bone mineralization. Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide. Can generate outwardly rectifying chloride channel currents in airway epithelial cells and Jurkat T lymphocytes.; Upon SARS coronavirus-2/SARS-CoV-2 infection, is activated by spike protein which increases the amplitude of spontaneous Ca(2+) signals and is required for spike-mediated syncytia.
Target Involvement
Scott syndrome (SCTS)
Target Subcellular Location
Cell membrane; Multi-pass membrane protein. Note=Shows an intracellular localization according to PubMed:22075693.
Target Protein Families
Anoctamin family
Target Tissue Specificity
Expressed in embryonic stem cell, fetal liver, retina, chronic myologenous leukemia and intestinal cancer.
Target Synonyms
2900059G15Rik; AA407480; Ano6; ANO6_HUMAN; Anoctamin 6; Anoctamin-6; AW554778; BDPLT7; F730003B03Rik; MGC104751; SCTS; TMEM16F; Transmembrane protein 16F
Target Background
This gene encodes a multi-pass transmembrane protein that belongs to the anoctamin family. This protein is an essential component for the calcium-dependent exposure of phosphatidylserine on the cell surface. The scrambling of phospholipid occurs in various biological systems, such as when blood platelets are activated, they expose phosphatidylserine to trigger the clotting system. Mutations in this gene are associated with Scott syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
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