Rabbit anti-Human ANXA13 Polyclonal Antibody

Uniprot Id

P27216

Target Species

Human

Target Name

ANXA13

Target Full Name

Annexin A13

Target Function

Binds to membranes enriched in phosphatidylserine or phosphatidylglycerol in a calcium-dependent manner. Half-maximal membrane binding requires about 60 uM calcium. Does not bind to membranes that lack phospholipids with an acidic headgroup.; Binds to membranes enriched in phosphatidylserine or phosphatidylglycerol in a calcium-dependent manner, but requires higher calcium levels for membrane binding than isoform A. Half-maximal membrane binding requires about 320 uM calcium.

Target Subcellular Location

Apical cell membrane. Cell membrane; Lipid-anchor. Cytoplasmic vesicle.

Target Protein Families

Annexin family

Target Tissue Specificity

Detected in epithelial cells in colon and jejunum (at protein level). Detected in epithelial cells in jejunum.

Target Synonyms

Annexin A13; Annexin XIII; Annexin; intestine-specific; Annexin-13; ANX 13; ANX A13; ANX13; ANX13_HUMAN; ANXA13; Intestine Specific Annexin; Intestine-specific annexin; ISA; MGC150460

Target Background

This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. The specific function of this gene has not yet been determined; however, it is associated with the plasma membrane of undifferentiated, proliferating endothelial cells and differentiated villus enterocytes. Alternatively spliced transcript variants encoding different isoforms have been identified.