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The antibody against AOAH was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 306-575 of human AOAH (NP_001628.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against AOAH was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 306-575 of human AOAH (NP_001628.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-01454A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | AOAH |
| Target Synonyms | AOAH | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | BxPC-3 | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 306-575 of human AOAH (NP_001628.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | P28039 | Immunogen Sequence |
Uniprot Id
P28039
Target Species
Human
Target Name
AOAH
Target Full Name
Acyloxyacyl hydrolase
Target Function
Removes the secondary (acyloxyacyl-linked) fatty acyl chains from the lipid A region of bacterial lipopolysaccharides. By breaking down LPS, terminates the host response to bacterial infection and prevents prolonged and damaging inflammatory responses. In peritoneal macrophages, seems to be important for recovery from a state of immune tolerance following infection by Gram-negative bacteria.
Target Subcellular Location
Secreted. Cytoplasmic vesicle.
Target Research Area
Immunology
Target Synonyms
Acyloxyacyl hydrolase (neutrophil); Acyloxyacyl hydrolase large subunit; AOAH; AOAH_HUMAN
Target Background
This locus encodes both the light and heavy subunits of acyloxyacyl hydrolase. The encoded enzyme catalyzes the hydrolysis of acyloxylacyl-linked fatty acyl chains from bacterial lipopolysaccharides, effectively detoxifying these molecules. The encoded protein may play a role in modulating host inflammatory response to gram-negative bacteria. Alternatively spliced transcript variants have been described.
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