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The antibody against AOAH was raised in rabbit using the Recombinant Human Acyloxyacyl hydrolase protein (180-254AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC.
The antibody against AOAH was raised in rabbit using the Recombinant Human Acyloxyacyl hydrolase protein (180-254AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC.
$299.00
Immunohistochemistry of paraffin-embedded human pancreatic cancer using AOAH Antibody at dilution of 1:1002
| Cat.No | ADC-12860A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | AOAH |
| Target Synonyms | Acyloxyacyl hydrolase (neutrophil) antibody; Acyloxyacyl hydrolase large subunit antibody; AOAH antibody; AOAH_HUMAN antibody | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IHC, WB |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Acyloxyacyl hydrolase protein (180-254AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P28039 |
Uniprot Id
P28039
Target Species
Human
Target Name
AOAH
Target Full Name
Acyloxyacyl hydrolase
Target Function
Removes the secondary (acyloxyacyl-linked) fatty acyl chains from the lipid A region of bacterial lipopolysaccharides. By breaking down LPS, terminates the host response to bacterial infection and prevents prolonged and damaging inflammatory responses. In peritoneal macrophages, seems to be important for recovery from a state of immune tolerance following infection by Gram-negative bacteria.
Target Subcellular Location
Secreted. Cytoplasmic vesicle.
Target Research Area
Immunology
Target Synonyms
Acyloxyacyl hydrolase (neutrophil); Acyloxyacyl hydrolase large subunit; AOAH; AOAH_HUMAN
Target Background
This locus encodes both the light and heavy subunits of acyloxyacyl hydrolase. The encoded enzyme catalyzes the hydrolysis of acyloxylacyl-linked fatty acyl chains from bacterial lipopolysaccharides, effectively detoxifying these molecules. The encoded protein may play a role in modulating host inflammatory response to gram-negative bacteria. Alternatively spliced transcript variants have been described.
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