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The antibody against AOC1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 20-300 of human AOC1 (NP_001082.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
The antibody against AOC1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 20-300 of human AOC1 (NP_001082.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
| Cat.No | ADA-09517A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | AOC1 |
| Target Synonyms | ABP; DAO; KAO; ABP1; DAO1; AOC1 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Mouse heart, Mouse kidney, Rat heart, Mouse liver, Rat kidney | Application | ELISA, WB, IF/ICC |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 20-300 of human AOC1 (NP_001082.2). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | P19801 | Immunogen Sequence |
Uniprot Id
P19801
Target Species
Human
Target Name
AOC1
Target Full Name
Diamine oxidase [copper-containing]
Target Function
Catalyzes the degradation of compounds such as putrescine, histamine, spermine, and spermidine, substances involved in allergic and immune responses, cell proliferation, tissue differentiation, tumor formation, and possibly apoptosis. Placental DAO is thought to play a role in the regulation of the female reproductive function.
Target Subcellular Location
Secreted, extracellular space.
Target Protein Families
Copper/topaquinone oxidase family
Target Tissue Specificity
Placenta and kidney.
Target Synonyms
ABP; Abp1; ABP1_HUMAN; Amiloride binding protein 1 (amine oxidase (copper containing)); Amiloride binding protein 1; Amiloride binding protein; Amiloride sensitive amine oxidase; Amiloride-binding protein; Amiloride-sensitive amine oxidase [copper-containing]; Amine oxidase copper domain containing protein 1; AOC1; DAO; DAO1; Diamine oxidase; Histaminase; KAO; Kidney amine oxidase
Target Background
This gene encodes a metal-binding membrane glycoprotein that oxidatively deaminates putrescine, histamine, and related compounds. The encoded protein is inhibited by amiloride, a diuretic that acts by closing epithelial sodium ion channels. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
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