Rabbit anti-Human AP3B2 Polyclonal Antibody

Uniprot Id

Q13367

Target Species

Human

Target Name

AP3B2

Target Full Name

AP-3 complex subunit beta-2

Target Function

Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals

Target Involvement

Epileptic encephalopathy, early infantile, 48 (EIEE48)

Target Subcellular Location

Cytoplasmic vesicle, clathrin-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus.

Target Protein Families

Adaptor complexes large subunit family

Target Tissue Specificity

Isoform 1 expression is specific to nervous system. Expressed in nerve terminal and cell body, and is associated with nerve-terminal vesicles. Expression seen in Purkinje cells, cortical neurons, neuroectodermal tumors and graded in cerebral cortex (deepe

Target Research Area

Neuroscience

Target Synonyms

Adapter-related protein complex 3 subunit beta-2; Adaptor protein complex AP-3 subunit beta-2; Adaptor related protein complex 3 beta 2 subunit; AP 3 complex subunit beta 2; AP-3 complex subunit beta-2; AP3B2; AP3B2_HUMAN; beta NAP; Beta-3B-adaptin; Beta3B adaptin; Beta3b; Clathrin assembly protein complex 3 beta 2 large chain; Clathrin assembly protein complex 3 beta-2 large chain; NAPTB; Neuron specific vesicle coat protein and cerebellar degeneration antigen; Neuron-specific vesicle coat protein beta-NAP; Neuronal adaptin like protein beta subunit