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The antibody against AP4B1 was raised in rabbit using the Recombinant Human AP-4 complex subunit beta-1 protein (201-500AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC.
The antibody against AP4B1 was raised in rabbit using the Recombinant Human AP-4 complex subunit beta-1 protein (201-500AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC.
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Immunohistochemistry of paraffin-embedded human testis tissue using AP4B1 Antibody at dilution of 1:1002
| Cat.No | ADC-25259A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | AP4B1 |
| Target Synonyms | AP4B1AP-4 complex subunit beta-1 antibody; AP-4 adaptor complex subunit beta antibody; Adaptor-related protein complex 4 subunit beta-1 antibody; Beta subunit of AP-4 antibody; Beta4-adaptin antibody | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IHC, WB |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human AP-4 complex subunit beta-1 protein (201-500AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9Y6B7 |
Uniprot Id
Q9Y6B7
Target Species
Human
Target Name
AP4B1
Target Full Name
AP-4 complex subunit beta-1
Target Function
Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asymmetric localization of somatodendritic proteins in neurons. AP-4 is involved in the recognition and binding of tyrosine-based sorting signals found in the cytoplasmic part of cargos, but may also recognize other types of sorting signal.
Target Involvement
Spastic paraplegia 47, autosomal recessive (SPG47)
Target Subcellular Location
Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein.
Target Protein Families
Adaptor complexes large subunit family
Target Tissue Specificity
Widely expressed.
Target Synonyms
AP4B1AP-4 complex subunit beta-1; AP-4 adaptor complex subunit beta; Adaptor-related protein complex 4 subunit beta-1; Beta subunit of AP-4; Beta4-adaptin
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