Rabbit anti-Human AP4M1 Polyclonal Antibody

Uniprot Id

O00189

Target Species

Human

Target Name

AP4M1

Target Full Name

AP-4 complex subunit mu-1

Target Function

Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asymmetric localization of somatodendritic proteins in neurons. Within AP-4, the mu-type subunit AP4M1 is directly involved in the recognition and binding of tyrosine-based sorting signals found in the cytoplasmic part of cargos. The adaptor protein complex 4 (AP-4) may also recognize other types of sorting signal.

Target Involvement

Spastic paraplegia 50, autosomal recessive (SPG50)

Target Subcellular Location

Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Early endosome.

Target Protein Families

Adaptor complexes medium subunit family

Target Tissue Specificity

Ubiquitous. Highly expressed in testis and lowly expressed in brain and lung.

Target Synonyms

Adapter-related protein complex 4 mu-1 subunit; Adaptor related protein complex 4 mu 1 subunit; Adaptor related protein complex AP 4 mu4 subunit; Adaptor related protein complex AP4 mu4 subunit; Adaptor-related protein complex AP-4; mu 1; AP 4 adapter complex mu subunit; AP 4 complex subunit mu 1; AP-4 adapter complex mu subunit; AP-4 complex subunit mu-1; AP4 adapter complex mu subunit; AP4 complex subunit mu 1; AP4M1; AP4M1_HUMAN; Ap4m4; CPSQ3; MU 4; Mu adaptin related protein 2; MU ARP2; Mu subunit of AP 4; Mu subunit of AP-4; Mu-adaptin-related protein 2; mu-ARP2; mu4; Mu4-adaptin; MUARP 2; MUARP2; SPG50