Rabbit anti-Human APLN Polyclonal Antibody

Uniprot Id

Q9ULZ1

Target Species

Human

Target Name

APLN

Target Full Name

Apelin

Target Function

Endogenous ligand for the apelin receptor (APLNR). Drives internalization of the apelin receptor. Apelin-36 dissociates more hardly than (pyroglu)apelin-13 from APLNR. Hormone involved in the regulation of cardiac precursor cell movements during gastrulation and heart morphogenesis. Has an inhibitory effect on cytokine production in response to T-cell receptor/CD3 cross-linking; the oral intake of apelin in the colostrum and the milk might therefore modulate immune responses in neonates. Plays a role in early coronary blood vessels formation. Mediates myocardial contractility in an ERK1/2-dependent manner. May also have a role in the central control of body fluid homeostasis by influencing vasopressin release and drinking behavior.; (Microbial infection) Endogenous ligand for the apelin receptor (APLNR), an alternative coreceptor with CD4 for HIV-1 infection. Inhibits HIV-1 entry in cells coexpressing CD4 and APLNR. Apelin-36 has a greater inhibitory activity on HIV infection than other synthetic apelin derivatives.

Target Subcellular Location

Secreted. Secreted, extracellular space.

Target Protein Families

Apelin family

Target Tissue Specificity

Expressed in the brain with highest levels in the frontal cortex, thalamus, hypothalamus and midbrain. Secreted by the mammary gland into the colostrum and the milk.

Target Synonyms

AGTRL1 ligand; APEL; APEL_HUMAN; Apelin 13; Apelin-13; APJ endogenous ligand; Apln; XNPEP2