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Rabbit anti-Human APOO Polyclonal Antibody, Biotin conjugated

The antibody against APOO was raised in rabbit using the Recombinant Human MICOS complex subunit MIC26 protein (26-198AA) as the immunogen. This antibody exists as a biotin conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.

ADC-00504A

The antibody against APOO was raised in rabbit using the Recombinant Human MICOS complex subunit MIC26 protein (26-198AA) as the immunogen. This antibody exists as a biotin conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.

$299.00

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Specifications


Cat.No ADC-00504A ClonalityPolyclonal
Host SpeciesRabbitTarget NameAPOO
Target SynonymsAPOO; FAM121B; MIC23; MIC26; My025; UNQ1866/PRO4302; MICOS complex subunit MIC26; Apolipoprotein O; MICOS complex subunit MIC23; Protein FAM121BFormLiquid
Species ReactivityHumanIsotypeIgG
Storage Buffer0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4Purification Method>95%, Protein G purified
ConjugateBiotin conjugatedApplicationELISA
StorageUpon receipt

Immunogen Information


Immunogen DescriptionRecombinant Human MICOS complex subunit MIC26 protein (26-198AA)Target SpeciesHuman
Immunogen SequenceComplete sequences for the immunogen, target protein, and peptides are available upon request.Uniprot IDQ9BUR5
Background Information
  • Uniprot Id

    Q9BUR5

  • Target Species

    Human

  • Target Name

    APOO

  • Target Full Name

    MICOS complex subunit MIC26

  • Target Function

    Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays a crucial role in crista junction formation and mitochondrial function. Can promote cardiac lipotoxicity by enhancing mitochondrial respiration and fatty acid metabolism in cardiac myoblasts. Promotes cholesterol efflux from macrophage cells. Detected in HDL, LDL and VLDL. Secreted by a microsomal triglyceride transfer protein (MTTP)-dependent mechanism, probably as a VLDL-associated protein that is subsequently transferred to HDL.

  • Target Subcellular Location

    Mitochondrion inner membrane; Single-pass membrane protein. Secreted. Mitochondrion. Golgi apparatus membrane. Endoplasmic reticulum membrane.

  • Target Protein Families

    Apolipoprotein O/MICOS complex subunit Mic27 family

  • Target Tissue Specificity

    Expressed in all tissues examined. Up-regulated in diabetic heart.

  • Target Synonyms

    APOO; FAM121B; MIC23; MIC26; My025; UNQ1866/PRO4302; MICOS complex subunit MIC26; Apolipoprotein O; MICOS complex subunit MIC23; Protein FAM121B

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