Rabbit anti-Human AQP2 Polyclonal Antibody

The antibody against AQP2 was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 147-271 of human AQP2 (NP_000477.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, IF/ICC, ELISA.

ADA-12164A

Number

Cat.No	ADA-12164A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	AQP2
Target Synonyms	NDI2; AQP-CD; WCH-CD; AQP2	Form	Liquid
Species Reactivity	Human, Mouse, Rat	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.05% proclin300, pH7.3.	Purification Method	Affinity purification
Positive Samples	293T	Application	ELISA, WB, IF/ICC, IHC-P

Cat.No

ADA-12164A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

AQP2

Target Synonyms

NDI2; AQP-CD; WCH-CD; AQP2

Form

Liquid

Species Reactivity

Human, Mouse, Rat

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.05% proclin300, pH7.3.

Purification Method

Affinity purification

Positive Samples

293T

Application

ELISA, WB, IF/ICC, IHC-P

Immunogen Description	A synthetic peptide corresponding to a sequence within amino acids 147-271 of human AQP2 (NP_000477.1).	Target Species	Human
Immunogen Sequence	ASTDERRGENPGTPALSIGFSVALGHLLGIHYTGCSMNPARSLAPAVVTGKFDDHWVFWIGPLVGAILGSLLYNYVLFPPAKSLSERLAVLKGLEPDTDWEEREVRRRQSVELHSPQSLPRGTKA	Uniprot ID	P41181

Immunogen Description

A synthetic peptide corresponding to a sequence within amino acids 147-271 of human AQP2 (NP_000477.1).

Target Species

Human

Immunogen Sequence

ASTDERRGENPGTPALSIGFSVALGHLLGIHYTGCSMNPARSLAPAVVTGKFDDHWVFWIGPLVGAILGSLLYNYVLFPPAKSLSERLAVLKGLEPDTDWEEREVRRRQSVELHSPQSLPRGTKA

Uniprot ID

P41181

Background Information

Uniprot Id

P41181
Target Species

Human
Target Name

AQP2
Target Full Name

Aquaporin-2
Target Function

Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Plays an essential role in renal water homeostasis.
Target Involvement

Diabetes insipidus, nephrogenic, autosomal (ANDI)
Target Subcellular Location

Apical cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein.
Target Protein Families

MIP/aquaporin (TC 1.A.8) family
Target Tissue Specificity

Expressed in collecting tubules in kidney medulla (at protein level). Detected in kidney.
Target Research Area

Signal Transduction
Target Synonyms

AQP2; Aquaporin-2; AQP-2; ADH water channel; Aquaporin-CD; AQP-CD; Collecting duct water channel protein; WCH-CD; Water channel protein for renal collecting duct
Target Background

This gene encodes a water channel protein located in the kidney collecting tubule. It belongs to the MIP/aquaporin family, some members of which are clustered together on chromosome 12q13. Mutations in this gene have been linked to autosomal dominant and recessive forms of nephrogenic diabetes insipidus.

Rabbit anti-Human AQP2 Polyclonal Antibody

Specifications

Immunogen Information

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