Rabbit anti-Human AQP2 Polyclonal Antibody

Uniprot Id

P41181

Target Species

Human

Target Name

AQP2

Target Full Name

Aquaporin-2

Target Function

Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Plays an essential role in renal water homeostasis.

Target Involvement

Diabetes insipidus, nephrogenic, autosomal (ANDI)

Target Subcellular Location

Apical cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein.

Target Protein Families

MIP/aquaporin (TC 1.A.8) family

Target Tissue Specificity

Expressed in collecting tubules in kidney medulla (at protein level). Detected in kidney.

Target Research Area

Signal Transduction

Target Synonyms

AQP2; Aquaporin-2; AQP-2; ADH water channel; Aquaporin-CD; AQP-CD; Collecting duct water channel protein; WCH-CD; Water channel protein for renal collecting duct

Target Background

This gene encodes a water channel protein located in the kidney collecting tubule. It belongs to the MIP/aquaporin family, some members of which are clustered together on chromosome 12q13. Mutations in this gene have been linked to autosomal dominant and recessive forms of nephrogenic diabetes insipidus.