Rabbit anti-Human AQP5 Polyclonal Antibody

The antibody against AQP5 was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 200-265 of human AQP5 (NP_001642.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.

ADA-11448A

Number

Cat.No	ADA-11448A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	AQP5
Target Synonyms	PPKB; AQP-5; AQP5	Form	Liquid
Species Reactivity	Mouse, Rat	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.01% thimerosal, pH7.3.	Purification Method	Affinity purification
Positive Samples	Mouse lung, Rat lung	Application	ELISA, WB, IHC-P

Cat.No

ADA-11448A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

AQP5

Target Synonyms

PPKB; AQP-5; AQP5

Form

Liquid

Species Reactivity

Mouse, Rat

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.01% thimerosal, pH7.3.

Purification Method

Affinity purification

Positive Samples

Mouse lung, Rat lung

Application

ELISA, WB, IHC-P

Immunogen Description	A synthetic peptide corresponding to a sequence within amino acids 200-265 of human AQP5 (NP_001642.1).	Target Species	Human
Immunogen Sequence	SPAHWVFWVGPIVGAVLAAILYFYLLFPNSLSLSERVAIIKGTYEPDEDWEEQREERKKTMELTTR	Uniprot ID	P55064

Immunogen Description

A synthetic peptide corresponding to a sequence within amino acids 200-265 of human AQP5 (NP_001642.1).

Target Species

Human

Immunogen Sequence

SPAHWVFWVGPIVGAVLAAILYFYLLFPNSLSLSERVAIIKGTYEPDEDWEEQREERKKTMELTTR

Uniprot ID

P55064

Background Information

Uniprot Id

P55064
Target Species

Human
Target Name

AQP5
Target Full Name

Aquaporin-5
Target Function

Forms a water-specific channel. Plays an important role in fluid secretion in salivary glands. Required for TRPV4 activation by hypotonicity. Together with TRPV4, controls regulatory volume decrease in salivary epithelial cells. Seems to play a redundant role in water transport in the eye, lung and in sweat glands.
Target Involvement

Keratoderma, palmoplantar, Bothnian type (PPKB)
Target Subcellular Location

Apical cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein.
Target Protein Families

MIP/aquaporin (TC 1.A.8) family
Target Tissue Specificity

Detected in skin eccrine sweat glands, at the apical cell membrane and at intercellular canaliculi (at protein level).
Target Research Area

Transport, Signal Transduction
Target Synonyms

AQP 5; AQP-5; AQP5; AQP5_HUMAN; Aquaporin 5; Aquaporin-5
Target Background

Aquaporin 5 (AQP5) is a water channel protein. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). Aquaporin 5 plays a role in the generation of saliva, tears and pulmonary secretions. AQP0, AQP2, AQP5, and AQP6 are closely related and all map to 12q13.

Rabbit anti-Human AQP5 Polyclonal Antibody

Specifications

Immunogen Information

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