Rabbit anti-Human ARHGEF1 Polyclonal Antibody

The antibody against ARHGEF1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 783-912 of human ARHGEF1 (NP_004697.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.

ADA-13168A

Number

Cat.No	ADA-13168A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	ARHGEF1
Target Synonyms	LSC; GEF1; IMD62; LBCL2; SUB1.5; P115-RHOGEF; F1	Form	Liquid
Species Reactivity	Human, Rat	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.01% thimerosal, pH7.3.	Purification Method	Affinity purification
Positive Samples	HeLa, Jurkat, LO2	Application	ELISA, WB, IHC-P

Cat.No

ADA-13168A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

ARHGEF1

Target Synonyms

LSC; GEF1; IMD62; LBCL2; SUB1.5; P115-RHOGEF; F1

Form

Liquid

Species Reactivity

Human, Rat

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.01% thimerosal, pH7.3.

Purification Method

Affinity purification

Positive Samples

HeLa, Jurkat, LO2

Application

ELISA, WB, IHC-P

Immunogen Description	Recombinant fusion protein containing a sequence corresponding to amino acids 783-912 of human ARHGEF1 (NP_004697.2).	Target Species	Human
Immunogen Sequence	PLLSSSENGNGGRETSPADARTERILSDLLPFCRPGPEGQLAATALRKVLSLKQLLFPAEEDNGAGPPRDGDGVPGGGPLSPARTQEIQENLLSLEETMKQLEELEEEFCRLRPLLSQLGGNSVPQPGCT	Uniprot ID	Q92888

Immunogen Description

Recombinant fusion protein containing a sequence corresponding to amino acids 783-912 of human ARHGEF1 (NP_004697.2).

Target Species

Human

Immunogen Sequence

PLLSSSENGNGGRETSPADARTERILSDLLPFCRPGPEGQLAATALRKVLSLKQLLFPAEEDNGAGPPRDGDGVPGGGPLSPARTQEIQENLLSLEETMKQLEELEEEFCRLRPLLSQLGGNSVPQPGCT

Uniprot ID

Q92888

Background Information

Uniprot Id

Q92888
Target Species

Human
Target Name

ARHGEF1
Target Full Name

Rho guanine nucleotide exchange factor 1
Target Function

Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits. Acts as GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase. Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain. This GEF activity is inhibited by binding to activated GNA12. Mediates angiotensin-2-induced RhoA activation.
Target Subcellular Location

Cytoplasm. Membrane. Note=Translocated to the membrane by activated GNA13 or LPA stimulation.
Target Tissue Specificity

Ubiquitously expressed.
Target Synonyms

115 kD protein; 115 kDa guanine nucleotide exchange factor; ARHG1_HUMAN; ARHGEF 1; ARHGEF1; GEF 1; GEF1; LBCL 2; LBCL2; LSC; Lsc homolog; p115 RhoGEF; p115-RhoGEF; p115RhoGEF; Rho guanine nucleotide exchange factor (GEF) 1; Rho guanine nucleotide exchange factor 1; Sub1.5
Target Background

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form complex with G proteins and stimulate Rho-dependent signals. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been defined.

Rabbit anti-Human ARHGEF1 Polyclonal Antibody

Specifications

Immunogen Information

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