Rabbit anti-Human ARHGEF9 Polyclonal Antibody

The antibody against ARHGEF9 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 307-516 of human ARHGEF9 (NP_056000.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

ADA-01848A

Number

Cat.No	ADA-01848A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	ARHGEF9
Target Synonyms	DEE8; PEM2; EIEE8; PEM-2; HPEM-2; COLLYBISTIN; ARHGEF9	Form	Liquid
Species Reactivity	Human, Mouse, Rat	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.02% sodium azide, pH7.3.	Purification Method	Affinity purification
Positive Samples	HeLa, 22Rv1, BT-474	Application	ELISA, WB

Cat.No

ADA-01848A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

ARHGEF9

Target Synonyms

DEE8; PEM2; EIEE8; PEM-2; HPEM-2; COLLYBISTIN; ARHGEF9

Form

Liquid

Species Reactivity

Human, Mouse, Rat

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.02% sodium azide, pH7.3.

Purification Method

Affinity purification

Positive Samples

HeLa, 22Rv1, BT-474

Application

ELISA, WB

Immunogen Description	Recombinant fusion protein containing a sequence corresponding to amino acids 307-516 of human ARHGEF9 (NP_056000.1).	Target Species	Human
Uniprot ID	O43307	Immunogen Sequence

Immunogen Description

Recombinant fusion protein containing a sequence corresponding to amino acids 307-516 of human ARHGEF9 (NP_056000.1).

Target Species

Human

Uniprot ID

O43307

Immunogen Sequence

Background Information

Uniprot Id

O43307
Target Species

Human
Target Name

ARHGEF9
Target Full Name

Rho guanine nucleotide exchange factor 9
Target Function

Acts as guanine nucleotide exchange factor (GEF) for CDC42. Promotes formation of GPHN clusters.
Target Involvement

Epileptic encephalopathy, early infantile, 8 (EIEE8)
Target Subcellular Location

Cytoplasm. Cell junction, synapse, postsynaptic density.
Target Tissue Specificity

Detected in brain. Detected at low levels in heart.
Target Synonyms

9630036L12Rik; A230067K14; ARHG9_HUMAN; Arhgef9; Cdc42 guanine nucleotide exchange factor (GEF) 9; Collybistin; collybistin I; EIEE8; HPEM 2; hPEM-2 collybistin; KIAA0424; mKIAA0424; OTTHUMP00000023424; OTTHUMP00000023425; OTTHUMP00000023427; PEM 2; PEM 2 homolog ; PEM-2 homolog; PEM2; Rac/Cdc42 guanine nucleotide exchange factor 9; Rho guanine nucleotide exchange factor 9; RP11 357C3.4; RP23 230K20.3
Target Background

The protein encoded by this gene is a Rho-like GTPase that switches between the active (GTP-bound) state and inactive (GDP-bound) state to regulate CDC42 and other genes. This brain-specific protein also acts as an adaptor protein for the recruitment of gephyrin and together these proteins facilitate receceptor recruitement in GABAnergic and glycinergic synapses. Defects in this gene are the cause of startle disease with epilepsy (STHEE), also known as hyperekplexia with epilepsy, as well as several other types of cognitive disability. Multiple transcript variants encoding different isoforms have been found for this gene.

Rabbit anti-Human ARHGEF9 Polyclonal Antibody

Specifications

Immunogen Information

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