Rabbit anti-Human ARL13B Polyclonal Antibody

Uniprot Id

Q3SXY8

Target Species

Human

Target Name

ARL13B

Target Full Name

ADP-ribosylation factor-like protein 13B

Target Function

Cilium-specific protein required to control the microtubule-based, ciliary axoneme structure. May act by maintaining the association between IFT subcomplexes A and B. Binds GTP but is not able to hydrolyze it; the GTPase activity remains unclear. Required to pattern the neural tube. Involved in cerebral cortex development: required for the initial formation of a polarized radial glial scaffold, the first step in the construction of the cerebral cortex, by regulating ciliary signaling. Regulates the migration and placement of postmitotic interneurons in the developing cerebral cortex. May regulate endocytic recycling traffic; however, additional evidence is required to confirm these data.

Target Involvement

Joubert syndrome 8 (JBTS8)

Target Subcellular Location

Cell projection, cilium membrane; Lipid-anchor. Cell projection, cilium. Note=Associates to the cilium membrane via palmitoylation. Localizes to proximal ciliary membranes, to an inversin-like subciliary membrane compartment, excluding the transition zone.

Target Protein Families

Small GTPase superfamily, Arf family

Target Tissue Specificity

Expressed in the developing brain.

Target Synonyms

ADP ribosylation factor like 13B; ADP ribosylation factor like 2 like 1 ; ADP-ribosylation factor-like protein 13B; ADP-ribosylation factor-like protein 2-like 1; AR13B_HUMAN; arl13b; ARL2-like protein 1; ARL2L1; JBTS8