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The antibody against ARNT2 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 440-690 of human ARNT2 (NP_055677.3) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against ARNT2 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 440-690 of human ARNT2 (NP_055677.3) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-09148A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | ARNT2 |
| Target Synonyms | WEDAS; bHLHe1; ARNT2 | Form | Liquid |
| Species Reactivity | Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Rat brain, Mouse brain | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 440-690 of human ARNT2 (NP_055677.3). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q9HBZ2 | Immunogen Sequence |
Uniprot Id
Q9HBZ2
Target Species
Human
Target Name
ARNT2
Target Full Name
Aryl hydrocarbon receptor nuclear translocator 2
Target Function
Transcription factor that plays a role in the development of the hypothalamo-pituitary axis, postnatal brain growth, and visual and renal function. Specifically recognizes the xenobiotic response element (XRE).
Target Involvement
Webb-Dattani syndrome (WEDAS)
Target Subcellular Location
Nucleus.
Target Synonyms
ARNT protein 2; ARNT2; ARNT2_HUMAN; Aryl hydrocarbon receptor nuclear translocator 2; bHLHe1; Class E basic helix-loop-helix protein 1
Target Background
This gene encodes a member of the basic-helix-loop-helix-Per-Arnt-Sim (bHLH-PAS) superfamily of transcription factors. The encoded protein acts as a partner for several sensor proteins of the bHLH-PAS family, forming heterodimers with the sensor proteins that bind regulatory DNA sequences in genes responsive to developmental and environmental stimuli. Under hypoxic conditions, the encoded protein complexes with hypoxia-inducible factor 1alpha in the nucleus and this complex binds to hypoxia-responsive elements in enhancers and promoters of oxygen-responsive genes. A highly similar protein in mouse forms functional complexes with both aryl hydrocarbon receptors and Single-minded proteins, suggesting additional roles for the encoded protein in the metabolism of xenobiotic compounds and the regulation of neurogenesis, respectively.
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