Rabbit anti-Human Arp3 Polyclonal Antibody

The antibody against Arp3 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-418 of human Arp3 (NP_005712.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.

ADA-10936A

Number

Cat.No	ADA-10936A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	Arp3
Target Synonyms	ARP3; Arp3	Form	Liquid
Species Reactivity	Human, Mouse	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.02% sodium azide, pH7.3.	Purification Method	Affinity purification
Positive Samples	HeLa, COS-1, COS-7, HL-60, Jurkat, K-562, Mouse spleen	Application	ELISA, WB, IF/ICC

Cat.No

ADA-10936A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

Arp3

Target Synonyms

ARP3; Arp3

Form

Liquid

Species Reactivity

Human, Mouse

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.02% sodium azide, pH7.3.

Purification Method

Affinity purification

Positive Samples

HeLa, COS-1, COS-7, HL-60, Jurkat, K-562, Mouse spleen

Application

ELISA, WB, IF/ICC

Immunogen Description	Recombinant fusion protein containing a sequence corresponding to amino acids 1-418 of human Arp3 (NP_005712.1).	Target Species	Human
Uniprot ID	P61158	Immunogen Sequence

Immunogen Description

Recombinant fusion protein containing a sequence corresponding to amino acids 1-418 of human Arp3 (NP_005712.1).

Target Species

Human

Uniprot ID

P61158

Immunogen Sequence

Background Information

Uniprot Id

P61158
Target Species

Human
Target Name

ACTR3
Target Full Name

Actin-related protein 3
Target Function

ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. In podocytes, required for the formation of lamellipodia downstream of AVIL and PLCE1 regulation. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs). Plays a role in ciliogenesis.
Target Subcellular Location

Cytoplasm, cytoskeleton. Cell projection. Nucleus. Note=In pre-apoptotic cells, colocalizes with MEFV in large specks (pyroptosomes) (PubMed:19109554).
Target Protein Families

Actin family, ARP3 subfamily
Target Research Area

Immunology
Target Synonyms

ACTR3; ARP3Actin-related protein 3; Actin-like protein 3
Target Background

The specific function of this gene has not yet been determined; however, the protein it encodes is known to be a major constituent of the ARP2/3 complex. This complex is located at the cell surface and is essential to cell shape and motility through lamellipodial actin assembly and protrusion. Three transcript variants encoding two different isoforms have been found for this gene.

Rabbit anti-Human Arp3 Polyclonal Antibody

Specifications

Immunogen Information

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