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The antibody against ASB4 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human ASB4 (NP_665879.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on IHC-P, ELISA.
The antibody against ASB4 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human ASB4 (NP_665879.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on IHC-P, ELISA.
Immunohistochemistry analysis of ASB4 in paraffin-embedded human liver using ASB4 Rabbit pAb at dilution of 1:100 (40x lens).Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
| Cat.No | ADA-06117A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | ASB4 |
| Target Synonyms | ASB-4; ASB4 | Form | Liquid |
| Species Reactivity | Human, Mouse | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Application | ELISA, IHC-P |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human ASB4 (NP_665879.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q9Y574 | Immunogen Sequence |
Uniprot Id
Q9Y574
Target Species
Human
Target Name
ASB4
Target Full Name
Ankyrin repeat and SOCS box protein 4
Target Function
Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes differentiation and maturation of the vascular lineage by an oxygen-dependent mechanism.
Target Protein Families
Ankyrin SOCS box (ASB) family
Target Synonyms
Ankyrin repeat and SOCS box containing 4; Ankyrin repeat and SOCS box containing protein 4 ; Ankyrin repeat and SOCS box protein 4; ASB 4; ASB-4; ASB4; ASB4_HUMAN
Target Background
The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. Multiple alternatively spliced transcript variants have been described for this gene but some of the full length sequences are not known.
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