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The antibody against ASCC3 was raised in rabbit using the Recombinant Human Activating signal cointegrator 1 complex subunit 3 protein (1-111AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, IHC.
The antibody against ASCC3 was raised in rabbit using the Recombinant Human Activating signal cointegrator 1 complex subunit 3 protein (1-111AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, IHC.
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Immunohistochemistry of paraffin-embedded human breast cancer using ASCC3 Antibody at dilution of 1:100
Immunohistochemistry of paraffin-embedded human placenta tissue using ASCC3 Antibody at dilution of 1:1002
Immunohistochemistry of paraffin-embedded human pancreatic tissue using ASCC3 Antibody at dilution of 1:1003
| Cat.No | ADC-44154A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | ASCC3 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. |
| Purification Method | Antigen affinity purified | Conjugate | Non-conjugated |
| Application | ELISA, IHC | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Activating signal cointegrator 1 complex subunit 3 protein (1-111AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q8N3C0 |
Uniprot Id
Q8N3C0
Target Species
Human
Target Name
ASCC3
Target Full Name
Activating signal cointegrator 1 complex subunit 3
Target Function
3'-5' DNA helicase involved in repair of alkylated DNA. Promotes DNA unwinding to generate single-stranded substrate needed for ALKBH3, enabling ALKBH3 to process alkylated N3-methylcytosine (3mC) within double-stranded regions. Also involved in activation of the ribosome quality control (RQC) pathway, a pathway that degrades nascent peptide chains during problematic translation. Drives the splitting of stalled ribosomes, as part of the ribosome quality control trigger (RQT) complex. Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation.
Target Subcellular Location
Nucleus. Nucleus speckle. Cytoplasm, cytosol.
Target Protein Families
Helicase family
Target Tissue Specificity
Ubiquitous.
Target Research Area
others
Target Synonyms
Activating signal cointegrator 1 complex subunit 3; ASC-1 complex subunit p200; ASC-1 complex subunit p200-KD subunit; ASC1p200; ascc3; ATP binding 1; B630009I04Rik; dJ121G13.4; DJ467N11.1; HELC1_HUMAN; HELIC1; Helicase; helicase; ATP binding 1; p200; RNA helicase family; RNAH; RP1-121G13.4; Trip4 complex subunit p200
Target Background
This gene encodes a protein that belongs to a family of helicases that are involved in the ATP-dependent unwinding of nucleic acid duplexes. The encoded protein is the largest subunit of the activating signal cointegrator 1 complex that is involved in DNA repair and resistance to alkylation damage. Alternate splicing results in multiple transcript variants.
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