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The antibody against ASTL was raised in rabbit using the Recombinant Human Astacin-like metalloendopeptidase protein (38-337AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
The antibody against ASTL was raised in rabbit using the Recombinant Human Astacin-like metalloendopeptidase protein (38-337AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
$299.00
Immunohistochemistry of paraffin-embedded human gastric cancer using ASTL Antibody at dilution of 1:100
Immunohistochemistry of paraffin-embedded human endometrial cancer using ASTL Antibody at dilution of 1:1002
| Cat.No | ADC-19602A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | ASTL |
| Target Synonyms | ASTLAstacin-like metalloendopeptidase antibody; EC 3.4.-.- antibody; Oocyte astacin antibody; Ovastacin antibody | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IHC |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Astacin-like metalloendopeptidase protein (38-337AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q6HA08 |
Uniprot Id
Q6HA08
Target Species
Human
Target Name
ASTL
Target Full Name
Astacin-like metalloendopeptidase
Target Function
Oocyte-specific oolemmal receptor involved in sperm and egg adhesion and fertilization. Plays a role in the polyspermy inhibition. Probably acts as a protease for the post-fertilization cleavage of ZP2. Cleaves the sperm-binding ZP2 at the surface of the zona pellucida after fertilization and cortical granule exocytosis, rendering the zona pellucida unable to support further sperm binding.
Target Subcellular Location
Cytoplasm. Cell membrane. Cytoplasmic vesicle, secretory vesicle, Cortical granule.
Target Protein Families
Peptidase M12A family
Target Tissue Specificity
Expressed in promyelocytic leukemia HL-60 cells, Burkitt's lymphoma Raji cells, and also in some ovarian carcinomas. Not detected in normal tissues.
Target Research Area
Signal Transduction
Target Synonyms
ASTLAstacin-like metalloendopeptidase; EC 3.4.-.-; Oocyte astacin; Ovastacin
Target Background
Predicted to enable aspartic-type peptidase activity; glutamic-type peptidase activity; and metalloendopeptidase activity. Predicted to be involved in several processes, including negative regulation of binding activity of sperm to zona pellucida; positive regulation of protein processing; and prevention of polyspermy. Predicted to be located in cortical granule and plasma membrane.
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