Rabbit anti-Human ASXL1 Polyclonal Antibody

The antibody against ASXL1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 70-250 of human ASXL1 (NP_056153.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

ADA-00874A

Number

Cat.No	ADA-00874A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	ASXL1
Target Synonyms	MDS; BOPS; ASXL1	Form	Liquid
Species Reactivity	Human, Mouse	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.02% sodium azide, pH7.3.	Purification Method	Affinity purification
Positive Samples	Mouse liver	Application	ELISA, WB

Cat.No

ADA-00874A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

ASXL1

Target Synonyms

MDS; BOPS; ASXL1

Form

Liquid

Species Reactivity

Human, Mouse

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.02% sodium azide, pH7.3.

Purification Method

Affinity purification

Positive Samples

Mouse liver

Application

ELISA, WB

Immunogen Description	Recombinant fusion protein containing a sequence corresponding to amino acids 70-250 of human ASXL1 (NP_056153.2).	Target Species	Human
Immunogen Sequence	LFYKLPGRISLFTLKKDALQWSRHPATVEGEEPEDTADVESCGSNEASTVSGENDVSLDETSSNASCSTESQSRPLSNPRDSYRASSQANKQKKKTGVMLPRVVLTPLKVNGAHVESASGFSGCHADGESGSPSSSSSGSLALGSAAIRGQAEVTQDPAPLLRGFRKPATGQMKRNRGEEI	Uniprot ID	Q8IXJ9

Immunogen Description

Recombinant fusion protein containing a sequence corresponding to amino acids 70-250 of human ASXL1 (NP_056153.2).

Target Species

Human

Immunogen Sequence

LFYKLPGRISLFTLKKDALQWSRHPATVEGEEPEDTADVESCGSNEASTVSGENDVSLDETSSNASCSTESQSRPLSNPRDSYRASSQANKQKKKTGVMLPRVVLTPLKVNGAHVESASGFSGCHADGESGSPSSSSSGSLALGSAAIRGQAEVTQDPAPLLRGFRKPATGQMKRNRGEEI

Uniprot ID

Q8IXJ9

Background Information

Uniprot Id

Q8IXJ9
Target Species

Human
Target Name

ASXL1
Target Full Name

Polycomb group protein ASXL1
Target Function

Probable Polycomb group (PcG) protein involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors, such as retinoic acid receptors (RARs) and peroxisome proliferator-activated receptor gamma (PPARG). Acts as coactivator of RARA and RXRA through association with NCOA1. Acts as corepressor for PPARG and suppresses its adipocyte differentiation-inducing activity. Non-catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1). Acts as a sensor of N(6)-methyladenosine methylation on DNA (m6A): recognizes and binds m6A DNA, leading to its ubiquitination and degradation by TRIP12, thereby inactivating the PR-DUB complex and regulating Polycomb silencing
Target Involvement

Bohring-Opitz syndrome (BOPS); Myelodysplastic syndrome (MDS)
Target Subcellular Location

Nucleus.
Target Protein Families

Asx family
Target Tissue Specificity

Widely expressed at low level. Expressed in heart, brain, skeletal muscle, placenta, pancreas, spleen, prostate, small intestine, colon, peripheral blood, leukocytes, bone marrow and fetal liver. Highly expressed in testes.
Target Synonyms

Additional sex combs like 1 (Drosophila); Additional sex combs like protein 1; Additional sex combs-like protein 1; ASXL1; ASXL1_HUMAN; KIAA0978; Putative Polycomb group protein ASXL1

Rabbit anti-Human ASXL1 Polyclonal Antibody

Specifications

Immunogen Information

Inquire Rabbit anti-Human ASXL1 Polyclonal Antibody Now

Related Products