Rabbit anti-Human ATN1 Polyclonal Antibody

The antibody against ATN1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 900-1040 of human ATN1 (NP_001007027.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.

ADA-07998A

Number

Cat.No	ADA-07998A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	ATN1
Target Synonyms	B37; HRS; NOD; DRPLA; CHEDDA; D12S755E; ATN1	Form	Liquid
Species Reactivity	Human	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.01% thimerosal, pH7.3.	Purification Method	Affinity purification
Positive Samples	293T	Application	ELISA, WB, IF/ICC

Cat.No

ADA-07998A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

ATN1

Target Synonyms

B37; HRS; NOD; DRPLA; CHEDDA; D12S755E; ATN1

Form

Liquid

Species Reactivity

Human

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.01% thimerosal, pH7.3.

Purification Method

Affinity purification

Positive Samples

293T

Application

ELISA, WB, IF/ICC

Immunogen Description	Recombinant fusion protein containing a sequence corresponding to amino acids 900-1040 of human ATN1 (NP_001007027.1).	Target Species	Human
Immunogen Sequence	RNHPFYVPLGAVDPGLLGYNVPALYSSDPAAREREREARERDLRDRLKPGFEVKPSELEPLHGVPGPGLDPFPRHGGLALQPGPPGLHPFPFHPSLGPLERERLALAAGPALRPDMSYAERLAAERQHAERVAALGNDPLA	Uniprot ID	P54259

Immunogen Description

Recombinant fusion protein containing a sequence corresponding to amino acids 900-1040 of human ATN1 (NP_001007027.1).

Target Species

Human

Immunogen Sequence

RNHPFYVPLGAVDPGLLGYNVPALYSSDPAAREREREARERDLRDRLKPGFEVKPSELEPLHGVPGPGLDPFPRHGGLALQPGPPGLHPFPFHPSLGPLERERLALAAGPALRPDMSYAERLAAERQHAERVAALGNDPLA

Uniprot ID

P54259

Background Information

Uniprot Id

P54259
Target Species

Human
Target Name

ATN1
Target Full Name

Atrophin-1
Target Function

Transcriptional corepressor. Recruits NR2E1 to repress transcription. Promotes vascular smooth cell (VSMC) migration and orientation. Corepressor of MTG8 transcriptional repression. Has some intrinsic repression activity which is independent of the number of poly-Gln (polyQ) repeats.
Target Involvement

Dentatorubral-pallidoluysian atrophy (DRPLA)
Target Subcellular Location

Nucleus. Cytoplasm, perinuclear region. Cell junction.
Target Tissue Specificity

Widely expressed in various tissues including heart, lung, kidney, ovary, testis, prostate, placenta, skeletal Low levels in the liver, thymus and leukocytes. In the adult brain, broadly expressed in amygdala, caudate nucleus, corpus callosum, hippocampus
Target Synonyms

ATN1; D12S755E; DRPLAAtrophin-1; Dentatorubral-pallidoluysian atrophy protein
Target Background

Dentatorubral pallidoluysian atrophy (DRPLA) is a rare neurodegenerative disorder characterized by cerebellar ataxia, myoclonic epilepsy, choreoathetosis, and dementia. The disorder is related to the expansion from 7-35 copies to 49-93 copies of a trinucleotide repeat (CAG/CAA) within this gene. The encoded protein includes a serine repeat and a region of alternating acidic and basic amino acids, as well as the variable glutamine repeat. Alternative splicing results in two transcripts variants that encode the same protein.

Rabbit anti-Human ATN1 Polyclonal Antibody

Specifications

Immunogen Information

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