Rabbit anti-Human ATP11B Polyclonal Antibody

Uniprot Id

Q9Y2G3

Target Species

Human

Target Name

ATP11B

Target Full Name

Phospholipid-transporting ATPase IF

Target Function

Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids, phosphatidylserines (PS) and phosphatidylethanolamines (PE), from the outer to the inner leaflet of intracellular membranes. May contribute to the maintenance of membrane lipid asymmetry in endosome compartment.

Target Subcellular Location

Recycling endosome membrane; Multi-pass membrane protein. Early endosome. Endoplasmic reticulum. Golgi apparatus, trans-Golgi network.

Target Protein Families

Cation transport ATPase (P-type) (TC 3.A.3) family, Type IV subfamily

Target Synonyms

ATPIF; ATPIR; ATP11B

Target Background

P-type ATPases, such as ATP11B, are phosphorylated in their intermediate state and drive uphill transport of ions across membranes. Several subfamilies of P-type ATPases have been identified. One subfamily transports heavy metal ions, such as Cu(2+) or Cd(2+). Another subfamily transports non-heavy metal ions, such as H(+), Na(+), K(+), or Ca(+). A third subfamily transports amphipaths, such as phosphatidylserine.