Rabbit anti-Human ATP6V1G1 Polyclonal Antibody

Uniprot Id

O75348

Target Species

Human

Target Name

ATP6V1G1

Target Full Name

V-type proton ATPase subunit G 1

Target Function

Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation.

Target Subcellular Location

Apical cell membrane.

Target Protein Families

V-ATPase G subunit family

Target Tissue Specificity

Kidney; localizes to early distal nephron, encompassing thick ascending limbs and distal convoluted tubules (at protein level). Ubiquitous.

Target Research Area

Transport

Target Synonyms

ATP 6G; ATP 6J; ATP6G; ATP6G1; ATP6GL; Atp6v1g1; ATPase H+ transporting lysosomal (vacuolar proton pump) member J; ATPase H+ transporting lysosomal 13kD V1 subunit G isoform 1; ATPase H+ transporting lysosomal 13kDa V1 subunit G1; ATPase H+ transporting lysosomal member J; ATPase H+ transporting lysosomal subunit G isoform 1; DKFZp547P234; V ATPase 13 kDa subunit 1; V ATPase G subunit 1; V-ATPase 13 kDa subunit 1; V-ATPase subunit G 1; V-type proton ATPase subunit G 1; Vacuolar ATP synthase subunit G 1; Vacuolar ATP synthase subunit G1; Vacuolar ATP synthase subunit M16; Vacuolar H+ ATPase G1; Vacuolar H+ ATPase subunit G 1; Vacuolar proton pump G subunit 1; Vacuolar proton pump subunit G 1; Vacuolar proton pump subunit M16; VATG1_HUMAN; Vma 10; Vma10