Rabbit anti-Human ATP6V1G2 Polyclonal Antibody

Uniprot Id

O95670

Target Species

Human

Target Name

ATP6V1G2

Target Full Name

V-type proton ATPase subunit G 2

Target Function

Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.

Target Subcellular Location

Melanosome. Note=Highly enriched in late-stage melanosomes.

Target Protein Families

V-ATPase G subunit family

Target Tissue Specificity

Brain.

Target Synonyms

ATP6G; ATP6G2; ATP6V1G2; ATPase H+ transporting lysosomal (vacuolar proton pump) subunit G; ATPase H+ transporting lysosomal 13kDa V1 subunit G2; H(+) transporting two sector ATPase subunit G2; NG 38; NG38; OTTHUMP00000036058; OTTHUMP00000036060; V ATPase 13 kDa subunit 2; V ATPase G subunit 2; V ATPase subunit G 2; V-ATPase 13 kDa subunit 2; V-ATPase subunit G 2; V-type proton ATPase subunit G 2; Vacuolar ATP synthase subunit G 2; Vacuolar proton pump G subunit 2; Vacuolar proton pump subunit G 2; VATG2_HUMAN; VMA 10; VMA10

Target Background

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of intracellular compartments of eukaryotic cells. V-ATPase dependent acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is one of three V1 domain G subunit proteins. This gene had previous gene symbols of ATP6G and ATP6G2. Alternatively spliced transcript variants encoding different isoforms have been described. Read-through transcription also exists between this gene and the downstream DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B (DDX39B) gene.