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The antibody against ATRIP was raised in rabbit using the Peptide sequence around phosphorylation site of serine 224 (H-V-S(p)-P-R) derived from Human ATRIP. as the immunogen. Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi This antibody has been validated on ELISA, WB, IHC.
The antibody against ATRIP was raised in rabbit using the Peptide sequence around phosphorylation site of serine 224 (H-V-S(p)-P-R) derived from Human ATRIP. as the immunogen. Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi This antibody has been validated on ELISA, WB, IHC.
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Western blot analysis of extracts from 292 cells, treated with UV (15mins), using ATRIP (Phospho-Ser224) antibody. The lane on the right is treated with the synthesized peptide.
Western blot analysis of extracts from 293 cells (Lane 2) and Hela cells (Lane 3), using ATRIP (Phospho-Ser224) Antibody. The lane on the left is treated with synthesized peptide.2
Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue, using ATRIP (Phospho-Ser224) antibody. The picture on the right is treated with the synthesized peptide.3
| Cat.No | ADC-40585A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | ATRIP |
| Form | Liquid | Species Reactivity | Human |
| Storage Buffer | PH 7.4, 0.02% sodium azide and 50% glycerol., 150mM NaCl, Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+) | Application | ELISA, IHC, WB |
| Storage | Upon receipt |
| Immunogen Description | Peptide sequence around phosphorylation site of serine 224 (H-V-S(p)-P-R) derived from Human ATRIP. | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q8WXE1 |
Uniprot Id
Q8WXE1
Target Species
Human
Target Name
ATRIP
Target Full Name
ATR-interacting protein
Target Function
Required for checkpoint signaling after DNA damage. Required for ATR expression, possibly by stabilizing the protein.
Target Subcellular Location
Nucleus. Note=Redistributes to discrete nuclear foci upon DNA damage.
Target Protein Families
ATRIP family
Target Tissue Specificity
Ubiquitous.
Target Synonyms
AGS1; ATIP; ATM and Rad3 related interacting protein; ATM and Rad3-related-interacting protein; ATR interacting protein; ATR-interacting protein; Atrip; ATRIP_HUMAN; DKFZp762J2115; FLJ12343; MGC20625; MGC21482; MGC26740
Target Background
This gene encodes an essential component of the DNA damage checkpoint. The encoded protein binds to single-stranded DNA coated with replication protein A. The protein also interacts with the ataxia telangiectasia and Rad3 related protein kinase, resulting in its accumulation at intranuclear foci induced by DNA damage. Multiple transcript variants encoding different isoforms have been found for this gene.
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