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The antibody against ATXN10 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 346-475 of human ATXN10 (NP_037368.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
The antibody against ATXN10 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 346-475 of human ATXN10 (NP_037368.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
| Cat.No | ADA-03925A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | ATXN10 |
| Target Synonyms | E46L; ATX10; SCA10; HUMEEP; ATXN10 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | HeLa, Mouse heart, Mouse kidney, 293T, HL-60, LO2, Mouse liver, Rat testis, SKOV3 | Application | ELISA, WB, IF/ICC |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 346-475 of human ATXN10 (NP_037368.1). | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | ETTNIFSNCGCVRAEGDISNVANGFKSHLIRLIGNLCYKNKDNQDKVNELDGIPLILDNCNISDSNPFLTQWVIYAIRNLTEDNSQNQDLIAKMEEQGLADASLLKKVGFEVEKKGEKLILKSTRDTPKP | Uniprot ID | Q9UBB4 |
Uniprot Id
Q9UBB4
Target Species
Human
Target Name
ATXN10
Target Full Name
Ataxin-10
Target Function
Necessary for the survival of cerebellar neurons. Induces neuritogenesis by activating the Ras-MAP kinase pathway. May play a role in the maintenance of a critical intracellular glycosylation level and homeostasis.
Target Involvement
Spinocerebellar ataxia 10 (SCA10)
Target Subcellular Location
Cytoplasm, perinuclear region.
Target Protein Families
Ataxin-10 family
Target Tissue Specificity
Expressed in the central nervous system.
Target Synonyms
Ataxin 10; Ataxin-10; ATX10_HUMAN; Atxn10; Brain protein E46 homolog; E46L; FLJ37990; HUMEEP; Like mouse brain protein E46; OTTHUMP00000197383; SCA10; Spinocerebellar ataxia 10; Spinocerebellar ataxia type 10 protein
Target Background
This gene encodes a protein that may function in neuron survival, neuron differentiation, and neuritogenesis. These roles may be carried out via activation of the mitogen-activated protein kinase cascade. Expansion of an ATTCT repeat from 9-32 copies to 800-4500 copies in an intronic region of this locus has been associated with spinocerebellar ataxia, type 10. Alternatively spliced transcript variants have been described.
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