Rabbit anti-Human AURKC Polyclonal Antibody

The antibody against AURKC was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 1-100 of human AURKC (NP_001015878.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.

ADA-09168A

Number

Cat.No	ADA-09168A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	AURKC
Target Synonyms	AIE2; AIK3; ARK3; AurC; SPGF5; STK13; HEL-S-90; aurora-C; AURKC	Form	Liquid
Species Reactivity	Human, Mouse, Rat	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.02% sodium azide, pH7.3.	Purification Method	Affinity purification
Positive Samples	Rat brain, 293T, BT-474, HepG2, Mouse ovary, Mouse pancreas, Mouse testis, SW620	Application	ELISA, WB, IHC-P

Cat.No

ADA-09168A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

AURKC

Target Synonyms

AIE2; AIK3; ARK3; AurC; SPGF5; STK13; HEL-S-90; aurora-C; AURKC

Form

Liquid

Species Reactivity

Human, Mouse, Rat

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.02% sodium azide, pH7.3.

Purification Method

Affinity purification

Positive Samples

Rat brain, 293T, BT-474, HepG2, Mouse ovary, Mouse pancreas, Mouse testis, SW620

Application

ELISA, WB, IHC-P

Immunogen Description	A synthetic peptide corresponding to a sequence within amino acids 1-100 of human AURKC (NP_001015878.1).	Target Species	Human
Immunogen Sequence	MSSPRAVVQLGKAQPAGEELATANQTAQQPSSPAMRRLTVDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQAHLQH	Uniprot ID	Q9UQB9

Immunogen Description

A synthetic peptide corresponding to a sequence within amino acids 1-100 of human AURKC (NP_001015878.1).

Target Species

Human

Immunogen Sequence

MSSPRAVVQLGKAQPAGEELATANQTAQQPSSPAMRRLTVDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQAHLQH

Uniprot ID

Q9UQB9

Background Information

Uniprot Id

Q9UQB9
Target Species

Human
Target Name

AURKC
Target Full Name

Aurora kinase C
Target Function

Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Plays also a role in meiosis and more particularly in spermatogenesis. Has redundant cellular functions with AURKB and can rescue an AURKB knockdown. Like AURKB, AURKC phosphorylates histone H3 at 'Ser-10' and 'Ser-28'. AURKC phosphorylates the CPC complex subunits BIRC5/survivin and INCENP leading to increased AURKC activity. Phosphorylates TACC1, another protein involved in cell division, at 'Ser-228'.
Target Involvement

Spermatogenic failure 5 (SPGF5)
Target Subcellular Location

Nucleus. Chromosome. Chromosome, centromere. Cytoplasm, cytoskeleton, spindle.
Target Protein Families

Protein kinase superfamily, Ser/Thr protein kinase family, Aurora subfamily
Target Tissue Specificity

Isoform 1 and isoform 2 are expressed in testis. Elevated expression levels were seen only in a subset of cancer cell lines such as Hep-G2, Huh-7 and HeLa. Expression is maximum at M phase.
Target Synonyms

AURKC; AIE 2; Aie1; AIE2; AIK 3; AIK3; ARK 3; ARK-3; ARK3; Aur C; AurC; Aurkc; AURKC_HUMAN; aurora 3; Aurora C; Aurora kinase C; aurora related kinase 3; Aurora-related kinase 3; Aurora/Ipl1 related kinase 3; Aurora/Ipl1-related kinase 3; Aurora/Ipl1/Eg2 protein 2; EC 2.7.11.1; Serine threonine protein kinase 13; serine/threonine kinase 13 (aurora/IPL1 like); serine/threonine protein kinase aurora C; Serine/threonine-protein kinase 13; Serine/threonine-protein kinase aurora-C; SPGF5; STK13
Target Background

This gene encodes a member of the Aurora subfamily of serine/threonine protein kinases. The encoded protein is a chromosomal passenger protein that forms complexes with Aurora-B and inner centromere proteins and may play a role in organizing microtubules in relation to centrosome/spindle function during mitosis. This gene is overexpressed in several cancer cell lines, suggesting an involvement in oncogenic signal transduction. Alternative splicing results in multiple transcript variants.

Rabbit anti-Human AURKC Polyclonal Antibody

Specifications

Immunogen Information

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