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The antibody against B2M was raised in rabbit using the Recombinant Human Beta-2-microglobulin protein (22-119AA) as the immunogen. This antibody exists as a non-conjugated isotype lgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB.
The antibody against B2M was raised in rabbit using the Recombinant Human Beta-2-microglobulin protein (22-119AA) as the immunogen. This antibody exists as a non-conjugated isotype lgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB.
$299.00
| Cat.No | ADC-54505A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | B2m |
| Form | Liquid | Species Reactivity | Human, Mouse |
| Isotype | lgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, WB | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Beta-2-microglobulin protein (22-119AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P61769 |
Uniprot Id
P61769
Target Species
Human
Target Name
B2M
Target Full Name
Beta-2-microglobulin
Target Function
Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. Exogenously applied M.tuberculosis EsxA or EsxA-EsxB (or EsxA expressed in host) binds B2M and decreases its export to the cell surface (total protein levels do not change), probably leading to defects in class I antigen presentation.
Target Involvement
Immunodeficiency 43 (IMD43); Amyloidosis 8 (AMYL8)
Target Subcellular Location
Secreted. Cell surface.;
Target Protein Families
Beta-2-microglobulin family
Target Synonyms
IMD43; beta 2 Microglobulin
Target Background
This gene encodes a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. The encoded antimicrobial protein displays antibacterial activity in amniotic fluid. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia.
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