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The antibody against B3GNT5 was raised in rabbit using the Recombinant Human Lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase protein (65-344AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
The antibody against B3GNT5 was raised in rabbit using the Recombinant Human Lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase protein (65-344AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
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Immunohistochemistry of paraffin-embedded human testis tissue using B3GNT5 Antibody at dilution of 1:100
Immunohistochemistry of paraffin-embedded human lung tissue using B3GNT5 Antibody at dilution of 1:1002
| Cat.No | ADC-32873A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | B3GNT5 |
| Target Synonyms | 3-Gn-T5 antibody; Beta-1, 3-N-acetyl-beta-D-glucosaminyltransferase antibody; EC 2.4.1.206 antibody; Lactotriaosylceramide synthase antibody; Lc(3)Cer synthase antibody; Lc3 synthase antibody; UDP-GlcNAc:beta-Gal beta-1, 3-N-acetylglucosaminyltransferase 5 antibody; Beta3Gn-T5 antibody, 3-N-acetylglucosaminyltransferase 5 antibody; BGnT-5 antibody; Beta-1, B3GNT5Lactosylceramide 1 | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IHC |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase protein (65-344AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9BYG0 |
Uniprot Id
Q9BYG0
Target Species
Human
Target Name
B3GNT5
Target Full Name
Lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase
Target Function
Beta-1,3-N-acetylglucosaminyltransferase that plays a key role in the synthesis of lacto- or neolacto-series carbohydrate chains on glycolipids, notably by participating in biosynthesis of HNK-1 and Lewis X carbohydrate structures. Has strong activity toward lactosylceramide (LacCer) and neolactotetraosylceramide (nLc(4)Cer; paragloboside), resulting in the synthesis of Lc(3)Cer and neolactopentaosylceramide (nLc(5)Cer), respectively. Probably plays a central role in regulating neolacto-series glycolipid synthesis during embryonic development.
Target Subcellular Location
Golgi apparatus membrane; Single-pass type II membrane protein.
Target Protein Families
Glycosyltransferase 31 family
Target Tissue Specificity
Widely expressed. Highly expressed in lung, colon, placenta, testis, pituitary gland and cerebellum. Weakly expressed in brain, liver, spleen, lymph node and thymus.
Target Research Area
Tags & Cell Markers
Target Synonyms
B3GNT5Lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase; EC 2.4.1.206; Lactotriaosylceramide synthase; Lc(3)Cer synthase; Lc3 synthase; UDP-GlcNAc:beta-Gal beta-1,3-N-acetylglucosaminyltransferase 5; BGnT-5; Beta-1,3-Gn-T5; Beta-1,3-N-acetylglucosaminyltransferase 5; Beta3Gn-T5
Target Background
This gene encodes a member of the beta-1, 3-N-acetylglucosaminyltransferase family. This enzyme is a type II membrane protein. It exhibits strong activity to transfer GlcNAc to glycolipid substrates and is identified as the most likely candidate for lactotriaosylceramide synthase. This enzyme is essential for the expression of Lewis X epitopes on glycolipids.
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