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The antibody against B4GAT1 was raised in rabbit using the Recombinant Human Beta-1,4-glucuronyltransferase 1 protein (161-415AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
The antibody against B4GAT1 was raised in rabbit using the Recombinant Human Beta-1,4-glucuronyltransferase 1 protein (161-415AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
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Immunohistochemistry of paraffin-embedded human kidney tissue using B4GAT1 Antibody at dilution of 1:100
Immunohistochemistry of paraffin-embedded human brain tissue using B4GAT1 Antibody at dilution of 1:1002
| Cat.No | ADC-32871A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | B4GAT1 |
| Target Synonyms | 3-N-acetylglucosaminyltransferase 1, 3-N-acetylglucosaminyltransferase; iGnT; N-acetyllactosaminide beta-1, 3-N-acetylglucosaminyltransferase; Poly-N-acetyllactosamine extension enzyme; UDP-GlcNAc:betaGal beta-1, 4-glucuronyltransferase 1; I-beta-1, B4GAT1; B3GNT1; B3GNT6; Beta-1 | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IHC |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Beta-1,4-glucuronyltransferase 1 protein (161-415AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | O43505 |
Uniprot Id
O43505
Target Species
Human
Target Name
B4GAT1
Target Full Name
Beta-1,4-glucuronyltransferase 1
Target Function
Beta-1,4-glucuronyltransferase involved in O-mannosylation of alpha-dystroglycan (DAG1). Transfers a glucuronic acid (GlcA) residue onto a xylose (Xyl) acceptor to produce the glucuronyl-beta-1,4-xylose-beta disaccharide primer, which is further elongated by LARGE1, during synthesis of phosphorylated O-mannosyl glycan. Phosphorylated O-mannosyl glycan is a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity. Required for axon guidance; via its function in O-mannosylation of alpha-dystroglycan (DAG1).
Target Involvement
Muscular dystrophy-dystroglycanopathy congenital with brain and eye anomalies A13 (MDDGA13)
Target Subcellular Location
Golgi apparatus membrane; Single-pass type II membrane protein.
Target Protein Families
Glycosyltransferase 49 family
Target Tissue Specificity
In the adult, highly expressed in heart, brain, skeletal muscle and kidney and to a lesser extent in placenta, pancreas, spleen, prostate, testis, ovary, small intestine and colon. Very weak expression in lung, liver, thymus and peripheral blood leukocyte
Target Synonyms
B4GAT1; B3GNT1; B3GNT6; Beta-1,4-glucuronyltransferase 1; I-beta-1,3-N-acetylglucosaminyltransferase; iGnT; N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase; Poly-N-acetyllactosamine extension enzyme; UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1
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