Rabbit anti-Human BAG2 Monoclonal Antibody

The antibody against BAG2 was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 1-100 of human BAG2 (O95816) as the immunogen. The monoclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.

ADA-15845A

Number

Cat.No	ADA-15845A	Clonality	Monoclonal
Host Species	Rabbit	Target Name	BAG2
Target Synonyms	BAG-2; dJ417I1.2; BAG2	Form	Liquid
Species Reactivity	Human, Mouse, Rat	Isotype	IgG
Storage Buffer	50% Glycerol, 0.05% BSA, PBS with 0.02% sodium azide, pH7.3.	Purification Method	Affinity purification
Positive Samples	A549, Jurkat, PC-3	Application	ELISA, WB, IHC-P

Cat.No

ADA-15845A

Clonality

Monoclonal

Host Species

Rabbit

Target Name

BAG2

Target Synonyms

BAG-2; dJ417I1.2; BAG2

Form

Liquid

Species Reactivity

Human, Mouse, Rat

Isotype

IgG

Storage Buffer

50% Glycerol, 0.05% BSA, PBS with 0.02% sodium azide, pH7.3.

Purification Method

Affinity purification

Positive Samples

A549, Jurkat, PC-3

Application

ELISA, WB, IHC-P

Immunogen Description	A synthetic peptide corresponding to a sequence within amino acids 1-100 of human BAG2 (O95816).	Target Species	Human
Immunogen Sequence	MAQAKINAKANEGRFCRSSSMADRSSRLLESLDQLELRVEALREAATAVEQEKEILLEMIHSIQNSQDMRQISDGEREELNLTANRLMGRTLTVEVSVET	Uniprot ID	O95816

Immunogen Description

A synthetic peptide corresponding to a sequence within amino acids 1-100 of human BAG2 (O95816).

Target Species

Human

Immunogen Sequence

MAQAKINAKANEGRFCRSSSMADRSSRLLESLDQLELRVEALREAATAVEQEKEILLEMIHSIQNSQDMRQISDGEREELNLTANRLMGRTLTVEVSVET

Uniprot ID

O95816

Background Information

Uniprot Id

O95816
Target Species

Human
Target Name

BAG2
Target Full Name

BAG family molecular chaperone regulator 2
Target Function

Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release.
Target Research Area

Cell Biology
Target Synonyms

BAG 2; BAG family molecular chaperone regulator 2; BAG-2; BAG-family molecular chaperone regulator-2; Bag2; BAG2_HUMAN; BCL 2 associated athanogene 2; Bcl-2-associated athanogene 2; BCL2 associated athanogene 2; BCL2-associated athanogene 2; dJ417I1.2 (BAG family molecular chaperone regulator 2); dJ417I1.2; KIAA0576; MGC149462; OTTHUMP00000016668
Target Background

BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The predicted BAG2 protein contains 211 amino acids. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner.

Rabbit anti-Human BAG2 Monoclonal Antibody

Specifications

Immunogen Information

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