Rabbit anti-Human Bak Monoclonal Antibody

Uniprot Id

Q16611

Target Species

Human

Target Name

BAK1

Target Full Name

Bcl-2 homologous antagonist/killer

Target Function

Plays a role in the mitochondrial apoptosic process. Upon arrival of cell death signals, promotes mitochondrial outer membrane (MOM) permeabilization by oligomerizing to form pores within the MOM. This releases apoptogenic factors into the cytosol, including cytochrome c, promoting the activation of caspase 9 which in turn processes and activates the effector caspases.

Target Subcellular Location

Mitochondrion outer membrane; Single-pass membrane protein.

Target Protein Families

Bcl-2 family

Target Tissue Specificity

Expressed in a wide variety of tissues, with highest levels in the heart and skeletal muscle.

Target Synonyms

BAK1; BAK; BCL2L7; CDN1; Bcl-2 homologous antagonist/killer; Apoptosis regulator BAK; Bcl-2-like protein 7; Bcl2-L-7

Target Background

The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form oligomers or heterodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein localizes to mitochondria, and functions to induce apoptosis. It interacts with and accelerates the opening of the mitochondrial voltage-dependent anion channel, which leads to a loss in membrane potential and the release of cytochrome c. This protein also interacts with the tumor suppressor P53 after exposure to cell stress.