Rabbit anti-Human BANP Polyclonal Antibody

Uniprot Id

Q8N9N5

Target Species

Human

Target Name

BANP

Target Full Name

Protein BANP

Target Function

Controls V(D)J recombination during T-cell development by repressing T-cell receptor (TCR) beta enhancer function. Binds to scaffold/matrix attachment region beta (S/MARbeta), an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Represses cyclin D1 transcription by recruiting HDAC1 to its promoter, thereby diminishing H3K9ac, H3S10ph and H4K8ac levels. Promotes TP53 activation, which causes cell cycle arrest.

Target Subcellular Location

Nucleus.

Target Protein Families

BANP/SMAR1 family

Target Tissue Specificity

Down-regulated in breast cancer cell lines.

Target Synonyms

AAH09424; Banp; BANP_HUMAN; BEN domain-containing protein 1; BEND1; BTG3 associated nuclear protein isoform a; Btg3-associated nuclear protein; DKFZp761H172; FLJ 10177; FLJ 20538; FLJ10177; FLJ20538; Protein BANP; Scaffold/Matrix associated region 1; Scaffold/matrix-associated region-1-binding protein; SMAR 1; SMAR1; SMARBP 1; SMARBP1

Target Background

This gene encodes a protein that binds to matrix attachment regions. The protein forms a complex with p53 and negatively regulates p53 transcription, and functions as a tumor suppressor and cell cycle regulator. Multiple transcript variants encoding different isoforms have been found for this gene.