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The antibody against BBOX1 was raised in rabbit using the Recombinant Human Gamma-butyrobetaine dioxygenase protein (154-247AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
The antibody against BBOX1 was raised in rabbit using the Recombinant Human Gamma-butyrobetaine dioxygenase protein (154-247AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
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Immunohistochemistry of paraffin-embedded human kidney tissue using BBOX1 Antibody at dilution of 1:100
Immunofluorescent analysis of HepG2 cells using BBOX1 Antibody at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)2
| Cat.No | ADC-09593A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | BBOX1 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IF, IHC | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Gamma-butyrobetaine dioxygenase protein (154-247AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | O75936 |
Uniprot Id
O75936
Target Species
Human
Target Name
BBOX1
Target Full Name
Gamma-butyrobetaine dioxygenase
Target Function
Catalyzes the formation of L-carnitine from gamma-butyrobetaine.
Target Subcellular Location
Cytoplasm.
Target Protein Families
Gamma-BBH/TMLD family
Target Tissue Specificity
Highly expressed in kidney; moderately expressed in liver; very low expression in brain.
Target Research Area
Metabolism
Target Synonyms
2-oxoglutarate dioxygenase; BBH; BBOX 1; BBOX; Bbox1; BODG_HUMAN; Butyrobetaine (gamma) 2 oxoglutarate dioxygenase (gamma butyrobetaine hydroxylase) 1; G BBH; Gamma BBH; Gamma butyrobetaine 2 oxoglutarate dioxygenase 1; Gamma butyrobetaine dioxygenase; Gamma butyrobetaine hydroxylase; Gamma-BBH; Gamma-butyrobetaine; Gamma-butyrobetaine dioxygenase; Gamma-butyrobetaine hydroxylase
Target Background
This gene encodes gamma butyrobetaine hydroxylase which catalyzes the formation of L-carnitine from gamma-butyrobetaine, the last step in the L-carnitine biosynthetic pathway. Carnitine is essential for the transport of activated fatty acids across the mitochondrial membrane during mitochondrial beta-oxidation.
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