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The antibody against BBS5 was raised in rabbit using the Recombinant Human Bardet-Biedl syndrome 5 protein (224-317AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
The antibody against BBS5 was raised in rabbit using the Recombinant Human Bardet-Biedl syndrome 5 protein (224-317AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
$299.00
| Cat.No | ADC-03208A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | BBS5 |
| Target Synonyms | Bardet Biedl syndrome 5 protein antibody; Bardet-Biedl syndrome 5 protein antibody; BBS5 antibody; BBS5_HUMAN antibody | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IHC |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Bardet-Biedl syndrome 5 protein (224-317AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q8N3I7 |
Uniprot Id
Q8N3I7
Target Species
Human
Target Name
BBS5
Target Full Name
BBSome complex member BBS5
Target Function
The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for BBSome complex ciliary localization but not for the proper complex assembly.
Target Involvement
Bardet-Biedl syndrome 5 (BBS5)
Target Subcellular Location
Cell projection, cilium membrane. Cytoplasm. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite.
Target Protein Families
BBS5 family
Target Synonyms
Bardet Biedl syndrome 5 protein; Bardet-Biedl syndrome 5 protein; BBS5; BBS5_HUMAN
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