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The antibody against BCLAF1 was raised in rabbit using the Recombinant Human Bcl-2-associated transcription factor 1 protein (218-407AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IF.
The antibody against BCLAF1 was raised in rabbit using the Recombinant Human Bcl-2-associated transcription factor 1 protein (218-407AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IF.
$299.00
Immunofluorescent analysis of Hela cells using BCLAF1 Antibody at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
| Cat.No | ADC-08105A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | BCLAF1 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IF | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Bcl-2-associated transcription factor 1 protein (218-407AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9NYF8 |
Uniprot Id
Q9NYF8
Target Species
Human
Target Name
BCLAF1
Target Full Name
Bcl-2-associated transcription factor 1
Target Function
Death-promoting transcriptional repressor. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA.
Target Subcellular Location
Cytoplasm. Nucleus. Nucleus speckle. Nucleus, nucleoplasm.
Target Protein Families
BCLAF1/THRAP3 family
Target Tissue Specificity
Ubiquitous.
Target Synonyms
Bcl 2 associated transcription factor; Bcl-2-associated transcription factor 1; BCL2 associated transcription factor 1; BCLAF1; BCLF1_HUMAN; bK211L9.1; Btf; KIAA0164
Target Background
This gene encodes a transcriptional repressor that interacts with several members of the BCL2 family of proteins. Overexpression of this protein induces apoptosis, which can be suppressed by co-expression of BCL2 proteins. The protein localizes to dot-like structures throughout the nucleus, and redistributes to a zone near the nuclear envelope in cells undergoing apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene.
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