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The antibody against BCLAF1 was raised in rabbit using the Synthesized peptide derived from the Internal region of Human BTF. as the immunogen. This antibody exists as a non-conjugated isotype IgG. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on WB, ELISA.
The antibody against BCLAF1 was raised in rabbit using the Synthesized peptide derived from the Internal region of Human BTF. as the immunogen. This antibody exists as a non-conjugated isotype IgG. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on WB, ELISA.
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Western Blot analysis of 293 cells using BTF Polyclonal Antibody
Western Blot analysis of NIH-3T3 cells using BTF Polyclonal Antibody2
| Cat.No | ADC-39197A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | BCLAF1 |
| Form | Liquid | Species Reactivity | Human, Mouse, Rat |
| Isotype | IgG | Storage Buffer | 0.5% BSA and 0.02% sodium azide., Liquid in PBS containing 50% glycerol |
| Purification Method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | Conjugate | Non-conjugated |
| Application | ELISA, WB | Storage | Upon receipt |
| Immunogen Description | Synthesized peptide derived from the Internal region of Human BTF. | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9NYF8 |
Uniprot Id
Q9NYF8
Target Species
Human
Target Name
BCLAF1
Target Full Name
Bcl-2-associated transcription factor 1
Target Function
Death-promoting transcriptional repressor. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA.
Target Subcellular Location
Cytoplasm. Nucleus. Nucleus speckle. Nucleus, nucleoplasm.
Target Protein Families
BCLAF1/THRAP3 family
Target Tissue Specificity
Ubiquitous.
Target Synonyms
Bcl 2 associated transcription factor; Bcl-2-associated transcription factor 1; BCL2 associated transcription factor 1; BCLAF1; BCLF1_HUMAN; bK211L9.1; Btf; KIAA0164
Target Background
This gene encodes a transcriptional repressor that interacts with several members of the BCL2 family of proteins. Overexpression of this protein induces apoptosis, which can be suppressed by co-expression of BCL2 proteins. The protein localizes to dot-like structures throughout the nucleus, and redistributes to a zone near the nuclear envelope in cells undergoing apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene.
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