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The antibody against beta glucuronidase (GUSB) was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 382-651 of human beta glucuronidase (beta glucuronidase (GUSB)) (NP_000172.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against beta glucuronidase (GUSB) was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 382-651 of human beta glucuronidase (beta glucuronidase (GUSB)) (NP_000172.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-03659A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | beta glucuronidase (GUSB) |
| Target Synonyms | BG; MPS7; beta glucuronidase (GUSB) | Form | Liquid |
| Species Reactivity | Mouse | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Mouse skeletal muscle | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 382-651 of human beta glucuronidase (beta glucuronidase (GUSB)) (NP_000172.2). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | P08236 | Immunogen Sequence |
Uniprot Id
P08236
Target Species
Human
Target Name
GUSB
Target Full Name
Beta-glucuronidase
Target Function
Plays an important role in the degradation of dermatan and keratan sulfates.
Target Involvement
Mucopolysaccharidosis 7 (MPS7)
Target Subcellular Location
Lysosome.
Target Protein Families
Glycosyl hydrolase 2 family
Target Synonyms
Ac2-223; asd; Beta G1; Beta glucuronidase; Beta-G1; Beta-glucuronidase; BG; BGLR; BGLR_HUMAN; FLJ39445; Glucuronidase beta; Gur; Gus; Gus-r; Gus-s; Gus-t; Gus-u; GUSB; Gut; MPS7
Target Background
This gene encodes a hydrolase that degrades glycosaminoglycans, including heparan sulfate, dermatan sulfate, and chondroitin-4, 6-sulfate. The enzyme forms a homotetramer that is localized to the lysosome. Mutations in this gene result in mucopolysaccharidosis type VII. Alternative splicing results in multiple transcript variants. There are many pseudogenes of this locus in the human genome.
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