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The antibody against BGLAP was raised in rabbit using the Recombinant Human Osteocalcin protein (52-100AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
The antibody against BGLAP was raised in rabbit using the Recombinant Human Osteocalcin protein (52-100AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
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Immunohistochemistry of paraffin-embedded human kidney tissue using BGLAP Antibody at dilution of 1:100
Immunohistochemistry of paraffin-embedded human liver cancer using BGLAP Antibody at dilution of 1:1002
| Cat.No | ADC-46413A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | BGLAP |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IHC | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Osteocalcin protein (52-100AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P02818 |
Uniprot Id
P02818
Target Species
Human
Target Name
BGLAP
Target Full Name
Osteocalcin
Target Function
Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium.
Target Subcellular Location
Secreted.
Target Protein Families
Osteocalcin/matrix Gla protein family
Target Synonyms
OC; BGP; OCN; Osteocalcin (BGLAP)
Target Background
This gene encodes a highly abundant bone protein secreted by osteoblasts that regulates bone remodeling and energy metabolism. The encoded protein contains a Gla (gamma carboxyglutamate) domain, which functions in binding to calcium and hydroxyapatite, the mineral component of bone. Serum osteocalcin levels may be negatively correlated with metabolic syndrome. Read-through transcription exists between this gene and the neighboring upstream gene, PMF1 (polyamine-modulated factor 1), but the encoded protein only shows sequence identity with the upstream gene product.
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