Rabbit anti-Human BHLHE40 Polyclonal Antibody

Uniprot Id

O14503

Target Species

Human

Target Name

BHLHE40

Target Full Name

Class E basic helix-loop-helix protein 40

Target Function

Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes. Acts as the negative limb of a novel autoregulatory feedback loop (DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors (PER/CRY loop). Both these loops are interlocked as it represses the expression of PER1/2 and in turn is repressed by PER1/2 and CRY1/2. Represses the activity of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1|ARNTL2/BMAL2 heterodimer by competing for the binding to E-box elements (5'-CACGTG-3') found within the promoters of its target genes. Negatively regulates its own expression and the expression of DBP and BHLHE41/DEC2. Acts as a corepressor of RXR and the RXR-LXR heterodimers and represses the ligand-induced RXRA and NR1H3/LXRA transactivation activity. May be involved in the regulation of chondrocyte differentiation via the cAMP pathway. Represses the transcription of NR0B2 and attentuates the transactivation of NR0B2 by the CLOCK-ARNTL/BMAL1 complex. Drives the circadian rhythm of blood pressure through transcriptional repression of ATP1B1 in the cardiovascular system.

Target Subcellular Location

Cytoplasm. Nucleus.

Target Tissue Specificity

Expressed in cartilage, spleen, intestine, lung, and to a lesser extent in heart, brain, liver, muscle and stomach.

Target Synonyms

BHE40_HUMAN; bHLHB2; bHLHe40; Class B Basic Helix Loop Helix Protein 2; Class B basic helix-loop-helix protein 2; Class E basic helix loop helix protein 40; Class E basic helix-loop-helix protein 40; Clast5; DEC1; Differentially expressed in chondrocytes protein 1; E47 interaction protein 1; EIP1; Enhancer of split and hairy related protein 2; Enhancer-of-split and hairy-related protein 2; SHARP 2; SHARP-2; Stimulated by retinoic acid gene 13 protein; STRA13

Target Background

This gene encodes a basic helix-loop-helix protein expressed in various tissues. The encoded protein can interact with ARNTL or compete for E-box binding sites in the promoter of PER1 and repress CLOCK/ARNTL's transactivation of PER1. This gene is believed to be involved in the control of circadian rhythm and cell differentiation.