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The antibody against BLOC1S3 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-202 of human BLOC1S3 (NP_997715.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on IHC-P, IF/ICC, ELISA.
The antibody against BLOC1S3 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-202 of human BLOC1S3 (NP_997715.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on IHC-P, IF/ICC, ELISA.
Immunohistochemistry analysis of BLOC1S3 in paraffin-embedded human colon using BLOC1S3 Rabbit pAb at dilution of 1:100 (40x lens).Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
| Cat.No | ADA-02078A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | BLOC1S3 |
| Target Synonyms | RP; HPS8; BLOS3; BLOC1S3 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Application | ELISA, IF/ICC, IHC-P |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-202 of human BLOC1S3 (NP_997715.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q6QNY0 | Immunogen Sequence |
Uniprot Id
Q6QNY0
Target Species
Human
Target Name
BLOC1S3
Target Full Name
Biogenesis of lysosome-related organelles complex 1 subunit 3
Target Function
Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking.
Target Involvement
Hermansky-Pudlak syndrome 8 (HPS8)
Target Subcellular Location
Cytoplasm.
Target Protein Families
BLOC1S3 family
Target Synonyms
Biogenesis of lysosomal organelles complex 1 subunit 3; Biogenesis of lysosome-related organelles complex 1 subunit 3; BL1S3_HUMAN; BLOC-1 subunit 3; Bloc1s3; BLOS3; HPS8; reduced pigmentation; mouse; homolog of; RP
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