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The antibody against BMF was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-184 of human BMF (NP_277038.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against BMF was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-184 of human BMF (NP_277038.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-09645A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | BMF |
| Target Synonyms | BMF | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Mouse liver, Mouse lung, Mouse ovary, Mouse spleen, Rat liver, SW480, U-937 | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-184 of human BMF (NP_277038.1). | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | MEPSQCVEELEDDVFQPEDGEPVTQPGSLLSADLFAQSLLDCPLSRLQLFPLTHCCGPGLRPTSQEDKATQTLSPASPSQGVMLPCGVTEEPQRLFYGNAGYRLPLPASFPAVLPIGEQPPEGQWQHQAEVQIARKLQCIADQFHRLHVQQHQQNQNRVWWQILLFLHNLALNGEENRNGAGPR | Uniprot ID | Q96LC9 |
Uniprot Id
Q96LC9
Target Species
Human
Target Name
BMF
Target Full Name
Bcl-2-modifying factor
Target Function
May play a role in apoptosis. Isoform 1 seems to be the main initiator.
Target Protein Families
Bcl-2 family
Target Tissue Specificity
Isoform 1 is mainly expressed in B-lymphoid cells. Isoform 2 and isoform 3 are mainly expressed in B-CLL and normal B-cells.
Target Research Area
Cell Biology
Target Synonyms
Bcl 2 modifying factor; Bcl-2-modifying factor; Bcl2 modifying factor; Bmf; BMF_HUMAN; FLJ00065
Target Background
The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein contains a single BCL2 homology domain 3 (BH3), and has been shown to bind BCL2 proteins and function as an apoptotic activator. This protein is found to be sequestered to myosin V motors by its association with dynein light chain 2, which may be important for sensing intracellular damage and triggering apoptosis. Alternatively spliced transcript variants encoding different isoforms have been identified.
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